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Xunrong Luo to speak about transplantation tolerance at Virginia Tech Life Science Seminar

From: The Fralin Life Sciences Institute

Xunrong Luo, a transplant immunologist at the Duke University School of Medicine, will speak at the Virginia Tech Life Science Seminar (VTLSS) on Friday, Feb. 26, at noon. VTLSS is a university-wide seminar series funded by the Fralin Life Sciences Institute at Virginia Tech.

When: Friday, Feb. 26, at noon

Host: Xin Lou

Talk Title: “Transplantation Tolerance Can Be Achieved…Now What?”

Abstract: Despite significant advances in prevention and treatment of transplant rejection with immunosuppressive medications, we continue to face challenges of long-term graft survival, detrimental medication side effects to both the recipient and transplanted organ together with risks for opportunistic infections.

Transplantation tolerance has so far only been clinically achieved through hematopoietic chimerism, which carries with it a serious and life-threatening risk of graft versus host disease, along with variability in persistence of chimerism and uncertainty of sustained tolerance. More recently, numerous in vitro and in vivo studies have explored the therapeutic potential of silent clearance of apoptotic cells which have been well known to aid in maintaining peripheral tolerance to self.

Apoptotic cells from a donor not only have the ability of down regulating the immune response, but also are a way of providing donor antigens to recipient antigen-presenting-cells that can then promote donor-specific transplant tolerance. Once achieved, however, opportunistic infections and reactivation of latent viruses pose a considerable challenge to the stability of tolerance, and may further promote anti-donor memory response and recipient sensitization.

This talk will focus on the mechanisms of tolerance induction by donor apoptotic cells and of tolerance disruption by opportunistic infections, and briefly discuss strategies for tolerance maintenance once achieved.

Join the virtual seminar live:

Missed it? Watch the recording here: